Priming with alcuronium and tubocurarine accelerates the onset of neuromuscular block.
نویسنده
چکیده
The individual rate of onset of action of tubocurarine and alcuronium has been examined with and without a priming dose of the same agent or the other agent, by measurement of changes in the evoked compound electromyogram of the adductor pollicis muscle. Priming was associated with acceleration of the onset of neuromuscular block.
منابع مشابه
Train-of-four fade during onset and recovery of neuromuscular block: a study in non-anaesthetized subjects.
The actions of alcuronium, vecuronium and tubocurarine have been studied in the isolated forearms of six healthy, non-anaesthetized volunteers. The responses of adductor pollicis were measured during onset and recovery of neuromuscular block for each agent. There was a drug-related disparity between mechanomyogram (MMG) and electromyogram (EMG) measurement of the first response of the train-of-...
متن کاملIn vitro investigation of the priming principle for rapid neuromuscular block.
The priming principle was investigated in the rat phrenic nerve-diaphragm preparation stimulated continuously at 0.2 Hz. Tubocurarine was added to the organ bath as either a single (non-primed) or a divided (primed) dose. Priming consisted of 15% or 20% of the final dose, with priming intervals of 5 or 10 min. Priming decreased significantly the time to 80% block and was associated with mild ne...
متن کاملInteractions between tubocurarine, pancuronium and alcuronium demonstrated in the rat phrenic nerve-hemidiaphragm preparation.
The interactions between tubocurarine, pancuronium and alcuronium on neuromuscular transmission have been studied in an isolated neuromuscular preparation (the rat phrenic nerve-hemidiaphragm). Mixtures of tubocurarine and pancuronium, and tubocurarine and alcuronium were found to have a more potent effect than the additive effects of the individual agents when given alone, that is, mixtures we...
متن کاملAntagonists to neuromuscular blocking agents. An experimental study.
T h : antagonism between tubocurarine and alcuronium chloride on the one hand and neostigmine, physostigmine, edrophonium and ambenonium on the other have been investigated. A quantitative measure of antagonism was obtained on the rat diaphragm preparation and it was found that in general the antagonists were more effective against alcuronium chloride than against tubocurarine. The antagonist d...
متن کاملPriming and the onset of neuromuscular blockade with alcuronium.
"Priming" with alcuronium has been studied in 72 female patients. Blockade of single twitch responses of the adductor pollicis by alcuronium 0.15, 0.2 or 0.3 mg kg-1 could be accelerated by priming with a suitable priming portion of the total dose. Giving alcuronium 0.04 mg kg-1 30 s after the induction of anaesthesia, followed by the balance 4 min later, resulted in more rapid neuromuscular bl...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- British journal of anaesthesia
دوره 63 1 شماره
صفحات -
تاریخ انتشار 1989